F-2015-DH5 (May: Photoprotection)

-Contains the titles of the abstracts dealing on particular topic: Acne, Psoriasis...(Prof. JH Saurat M.D.)
-To view the abstracts, please click on the link at the top of the 1st post. This redirects you to the journal of the matching issue.

F-2015-DH5 (May: Photoprotection)

Postby CFH » Sun May 10, 2015 9:24 pm

Page 8: http://dermatologicahelvetica.com/en/ar ... clesID=115

1-Today parents manage better / De nos jours, les parents protègent mieux leurs enfants du soleil

2-The mean daily sun exposure time to maintain healthy skin until 80 years is… / Le temps d'exposition quotidienne au soleil pour maintenir une peau sane jusqu'à 80 ans est de….

3-Tan with UVA-rich sunlamps prior to a holiday is counterproductive. / Le bronzage en cabine avec des lumières UVA avant de partir en vacances est inutile.

4-Sunscreen plus DNA repair enzyme in a tube / Xéroderma Pigmentosum: Les avantages de se protéger du soleil et ajout d'une enzyme qui répare l'ADN

5-Skin phototype is a 'biochemical fingerprint' / Chaque phototype cutané a ses caractéristiques biochimiques

6-Like fathers / like sons / Tel père - tel fils

7-Metformin: a potential drug to treat hyperpigmentation disorders. / La metformine dans le traitement des troubles hyperpigmentaires

8-Tacrolimus as maintenance in repigmented vitiligo / Le tacrolimus comme traitement de maintenance du vitiligo
CFH
Site Admin
 
Posts: 68
Joined: Tue Feb 24, 2015 7:29 pm

Re: F-2015-DH5 (May: Photoprotection)

Postby CFH » Fri May 15, 2015 10:39 am

2-The mean daily sun exposure time to maintain healthy skin until 80 years is… / Le temps d'exposition quotidienne au soleil pour maintenir une peau sane jusqu'à 80 ans est de….

Results (in the summer, between 10am and 2pm)
-2.54 minutes without sunscreen
-127 minutes with sunscreen (SPF 50 and above)

Comments
-The authors considered that sundamage occured after 35 years of sunexposure (35 times the annual average MED)
-In this study the authors considered that the cumlative annual dose of UV received (200 times (MED)) was similar in children and in adults. It differs from reality since on average half of the sun exposure is done at age 18 (In the US). One Caveat: this study is done in Japan and the sun behavior is very different from that in the United States.
CFH
Site Admin
 
Posts: 68
Joined: Tue Feb 24, 2015 7:29 pm

Re: F-2015-DH5 (May: Photoprotection)

Postby CFH » Thu May 21, 2015 11:07 am

7-Metformin: a potential drug to treat hyperpigmentation disorders. / La metformine dans le traitement des troubles hyperpigmentaires

Inhibition of melanogenesis by the antidiabetic metformin. Lehraiki A. et al. J Invest Dermatol. 2014 Oct;134(10):2589-97. doi: 10.1038/jid.2014.202. Epub 2014 Apr 22.

This is an interesting in vitro and in vivo study about the effects of metformin on pigmentation
-It was shown to reduce cyclicalAMP as well as genes involved in melanogenesis (MITF...)
-topical application in mice resulted in tail whitening

However it remains to be seen how this translates into clinical practice (in humans):
-for which indications ?
-by comparing it with standard depigmentants such as hydroquinone and existing non-hydroquinone based ones (For a list of existing depigmenting agents, click here: http://www.tinyurl.com/naqqd84)

Metformin has already been shown to have several effects in Dermatology: to read a summary of a review that was published in the JEADV in 2013, click here: http://www.tinyurl.com/pvhfzdn
CFH
Site Admin
 
Posts: 68
Joined: Tue Feb 24, 2015 7:29 pm

Re: F-2015-DH5 (May: Photoprotection)

Postby CFH » Tue Jun 16, 2015 7:47 pm

8-Tacrolimus as maintenance in repigmented vitiligo / Le tacrolimus comme traitement de maintenance du vitiligo

-Twice weekly topical Tacrolimus 0.1% ointment (Protopic) application appears to be effective
-The best results maintenance of pigmentation appear to be with lesions located on the face and neck.
-According to the authors, the proposed regimen could also be applicable to topical steroids [medium strength such as mometosone furoate 0.1% (Elocon, Elomet, Elocom)]
-It is not clear whether the repigmentation was maintained with topical tacrolimus in patients who had initally obtained repigmentation with tacrolimus or with other methods (Topical steroids, phototherapy, excimer laser)

Original source: http://bit.ly/1KWoGBD
CFH
Site Admin
 
Posts: 68
Joined: Tue Feb 24, 2015 7:29 pm

Re: F-2015-DH5 (May: Photoprotection)

Postby CFH » Sun Jul 12, 2015 12:00 pm

3-Tan with UVA-rich sunlamps prior to a holiday is counterproductive. / Le bronzage en cabine avec des lumières UVA avant de partir en vacances est inutile.

Photobiological implications of melanin photoprotection after UVB-induced tanning of human skin but not UVA-induced tanning. Coelho SG. et al. Pigment Cell Melanoma Res. 2015 Mar;28(2):210-6. doi: 10.1111/pcmr.12331. Epub 2015 Jan 5.

“Use tanning beds to get a tan before the holidays” – this is often promoted to consumers.

Tanning beds is a method of tanning the skin. However there is 1 major problem coming from this uncontrolled Ultraviolet radiation (UV) on the skin:
-an increased risk of Skin Cancer, the worse of it being Malignant Melanoma (MM) which is linked to UVA exposure. (Photoaging is another issue)

In this US Government study
-Human skin was exposed with UVA and UVB during 2 weeks without causing redness (suberythemal)
-UV radiation dosage (A and/or B) of 1.5 times the dose needed to cause redness of the skin* was applied on the skin and then DNA damage was measured (=Sunprotection Factor (SPF) 1.5)

-Results showed that Melanin distribution and synthesis were affected and that even a UV exposure of 1.5 times MED was too much (caused erythema and DNA damage) !

There is also a false sense of security that using tanning beds before a holiday will protect the skin during tanning…this is something which is often promoted to consumers.

Results show that melanin is redistributed and although the skin can change in appearance, the SPF is less than 1.5. As a reminder SPF50 is now used in most sunscreens.

Comment
SPF1.5 or less is obtained with a skin which is “prepared” by Tanning Beds
–it gives a false sense of security and can encourage some to stay longer in the sun.
-without applying a sunscreen, an SPF of less than 1.5 is the only “protection” when an SPF of 30 or more would be needed.


*=Minimal Erythemal Dose (MED)


Original source: http://bit.ly/1JYe1rb
CFH
Site Admin
 
Posts: 68
Joined: Tue Feb 24, 2015 7:29 pm


Return to Focus

Who is online

Users browsing this forum: No registered users and 0 guests